HCG Hospitals, Jaipur

HCG Hospitals, Jaipur

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Bone Marrow Transplant (BMT)


Most of the body’s blood cells generate in the bone marrows – the soft and fatty tissues inside the bones. They also store most of the body’s blood cells. There are also specific cells in the marrow that are capable of giving rise to more cells of the same type and are known as stem cells. The stem cells play the main and most important role in bone marrow transplant.

Bone marrow transplant is performed when blood cells and stem cells are damaged or destroyed in the cancers of blood or bone marrow (multiple myeloma or leukaemia). The damaged cells are removed from the patient’s marrow, and healthy stem cells from the patient or from a donor are extracted and filtered to transplant in the patient’s bone marrow.
The Bone Marrow Transplant, in some diseases, is the only possible cure. Besides cancer, BMT is needed in diseases like thalassemia, autoimmune and other non-malignant diseases.

Bone Marrow Transplant Can –
· Replace the diseased bone marrow with healthy marrow
· Treat acute immune system disorders and diseases that affect the production of blood cells
· Regenerate new cells to fight leukaemia and cancers which cannot be killed by just chemotherapy or radiation
· Restore bone marrow and its function after heavy doses of chemotherapy or radiation
· Prevent further damage of marrow with genetically healthy functioning bone marrow
We,HCGHospitals Jaipur recommend consultation and important discussions with our specialists before the bone marrow transplants.
 
Types of BMT
Autologous bone marrow transplant: The patients’ stem cells are used for their own transplant
Allogeneic bone marrow transplant: The donor is selected based on their cells’ genetic match with that of the patient’s. Stem cells are then taken from an HLA matched donor
Siblings (matched related donor/MRD): Brothers/sisters are the first choice as donors, provided that their HLA type matches with that of the recipient
Parent/Children (Haploidentical stem cell transplant): A haploid-identical match is when the donor is a parent, and the genetic match is at least half identical to the recipient
Unrelated bone marrow transplants (UBMT) or matched unrelated donor (MUD): The HLA matched marrow are from an unrelated donor (found through bone marrow registries)
Umbilical cord blood transplant: Stem cells are taken from an umbilical cord immediately after delivery of an infant. The stem cells are tested, typed, counted, and frozen until they are needed for a transplant
 
Diseases that can be treated:
Malignant Disease:
· Multiple myeloma
· Relapsed Hodgkins Disease
· Relapsed Non-Hodgkins Lymphoma (NHL)
· Neuroblastoma
· Relapsed Ewings Sarcoma
· Metastatic Ewings Sarcoma
· Metastatic Germ cell tumours
· Medulloblastoma
· Other brain tumours / Other solid malignancy
· MDS
· AML
· High-risk ALL
· Relapsed or Refractory AML/ALL
· CML
· Refractory Lymphomas
· Myeloproliferative Neoplasms (MPN)
Non-Malignant Disease:
· Severe Autoimmune Diseases
· Multiple Sclerosis
· Aplastic Anemia
· Thalassemia
· Severe Immunodeficiency disorders
· Inherited Metabolic disorders

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